In subgroup analysis, patients with N0 presented significantly different prognosis when the ratio was divided by the median. Despite the bias in this study, such as the small sample size and the inclusion of tumours up to 3cm in size, the western world grew sceptical towards sublobar resections, and lobectomy became the treatment of choice for lung cancer. Several molecular pathways orchestrate the complex biological cell events during a metastatic cascade. Ce la stanno mettendo tutta per recuperare il tempo perduto, cercando di ridurre i rischi per la salute che deriveranno dal blocco delle attività sanitarie di marzo-maggio scorsi: tutte le visite che non state fatte e le operazioni chirurgiche rinviate a causa dell’emergenza Covid potrebbero tradursi, per una parte dei pazienti, in malattie diagnosticate e curate più tardi del dovuto.Una volta sceso il livello di emergenza, è stata (ed è, ancora, confermano i medici) la paura del Covid a tenere lontani i pazienti dai reparti ospealieri. Recently, we observed that in highly metastatic tumors, tumor endothelial cells interact with tumor cells by secretion of a small leucine‐rich repeat proteoglycan known as biglycan. In the New Lymph Node Map, station 4 is confirmed as m... Years of debates couldn't solve the discussion between the NSCLC assessment founded on CT scan and mediastinoscopy as in the Western countries and the refined extensive bronchoscopy, CT imaging and exploratory thoracotomy as practiced in Japan. Tumor size was a known prognostic factor for many cancers, including NSCLC. Tumor angiogenesis is regulated by several molecular signals and tumor‐derived factors. TEC express angiocrine factors to interact with tumor cells. Vascularized Biomaterials to Study Cancer Metastasis. Lobar bronchoplastic p... ... 1,4,7,15 Carcinosarcoma is a malignant tumor containing both carcinomatous and sarcomatous elements. Because EC in primary tumors are in close contact with tumor cells during intravasation, it is relevant that these have important roles in metastasis dissemination. The landscape of long non-coding RNAs in tumor stroma. Diagnostic E valuation of P ulmonary E mbolism D uring the COVID-19 P andemic (May 2020) Lionel S. Zuckier, Renée M. Moadel, Linda B. Haramati, and Leonard Freeman Journal of Nuclear … Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username. Burelli: «Operiamo fino a sera per ridurre le attese. [10], IL-25 also induces IL-9 production in vivo.[11]. (b) Bisulfite sequencing analysis of the biglycan promoter in endothelial cells (EC). Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma. Slit2, which is negatively regulated by the endothelial EphA2 receptor, is one of the tumor suppressive angiocrine factors.49 The authors described that EphA2 represses Slit2 expression in EC to facilitate angiocrine‐mediated tumor invasion by blocking tumor suppressive signals.49 Such juxtacrine signals between EC and adjacent tumor cells could induce protumorigenic characteristics with increased expression of tumor‐stimulating factors or reduced expression of tumor‐suppressive factors. Vi ricordate la canzone di Vittorio Merlo, La Chiesa ti uccide coll'onda? Tumor microenvironment is formed by tumor and stromal cells and extracellular matrix (ECM). Understanding the molecular mechanisms underlying tumor metastasis is crucial to control this fatal disease. Stage migration due to new methods of diagnostic imaging and staging invasive procedures could improve actuarial survival in each stage. 1). In the present review, we highlight the role of tumor stromal cells, particularly endothelial cells, in the initial steps of tumor metastasis. [29] On the other hand patients suffering hepatocellular carcinoma with high TH9 infiltration had shorter disease-free survival period after surgical resection.[32]. There were several publications trying to elucidate role of TH9 cells in chronic HBV infection with inconsistent results. Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers. Simultaneous Tumor and Stroma Targeting by Oncolytic Viruses. "Fatele Vedere" è il nome della nuova Campagna di Prevenzione al Seno organizzata dalla LILT, la Lega Italiana per la Lotta ai Tumori. It is well known that tumor progression and metastasis are not dependent on a tumor cell‐autonomous mechanism, but are controlled by the tumor microenvironment, including abnormal stromal cells.6 Fibroblasts are among the major components of tumor stroma.7 As tumors are considered wounds that do not heal,8 chronic tissue repair response occurs in tumor tissues, which causes tumor fibrosis. X���yl{�%~�re];��t��v���l9�l�d�ʲ�$�mY(m��V$��mH�[�6�&c� �,��e�"�\�CI�2Ɇ�ۆ\�/�6@�h�F���}q�����* M1���9�;�m�����o�߶�m�����`K�c�|�$8��6��m��xr��&�X�7'��L>�]Jұ�o�N&&%|����Mbb��߰��-���c��;v�� n�N���=�����D7��c�������o�I�.�Db�7� �I �)7q�$'$��'����фN���[z��cY�jK������TR�gNAs�e`VU����O婰�'��w?$T��&�)� ��MO,��ۄ�o�O>�Pp�ۄ��ԄߦOHGt�&�~����N"��_���F~=ﱄc�S�����>C��b�����۔�c�Q�K/��M���%����)��h�:���R~:�/�R-�/*�{y�n�.�ح��c����ؿ-8w����cw~8{�n�����ԱK��M��[�x./-�,+;�033!/35!�7G��&�&����|�p�(91�X*�w�>!�������䤤c�&���L��X�ɤc�M9q,;%�XzZⱌԔc���&%1�8��oО����K�Pi��5�^���� �����r�d�Ze?c��e��|��n�'����{Ep�(�sNÝӥ�5�Kc�\��(|2�� �[=�o�XZ{i5�}Y\++'�63���0�޿�7�e����� ei� �� �u�滋g���c����ߎq�G�W�3 N����R�i~�� ��߳3ƹ�����C��(������o���>����s��.�,#/�(-;�쌄��9HgK�Zy�(̈́k��p��j��F^)�< ��΀{������ˇYip>� .dg����P�p>+�� ��p�d$&&$�����`��WܡÏ)��@G�eh:] s�Q޲+ �H��K>�r[;%YÞi�nn���Eg���K�T!�Z�(���]ӄvď�-�65/e�vu�[7v[��BN/���W��O��_�[����]]-�����:��P������ �����P�Ơ�߿���#��R�� ����ߊr�;����A�߾��8;&�r���P/ �'���?�f��_��1 Jg�c���s[�m]��B[E���3;�����_EF�}��]c8�X�����c�����7�n@��Vx�w�U��R^u'�A���"�r�Hz) �kޥF�Z]w:�����M��̫p'�<5��'�g���UķW�+`L�.��n�����Rw<. In turn, Jagged1 on EC reciprocally induces Notch2–Hey1 in lymphoma cells.42 Cao et al. [28] This is likely mediated by local and/or systemic production of Interleukin-9, as well as promoted survival of other anti-parasitic leukocytes, including mast cells, eosinophils and basophils. The Roles of Tissue Rigidity and Its Underlying Mechanisms in Promoting Tumor Growth. AF cells were subcutaneously injected into CD nu/nu mice and tumor masses were observed 20 days later. Tumore, 45 giorni per l’intervento con l'ospedale sotto pressione per il Covid La corsa di Senologia a Treviso per recuperare i ritardi. Stroma components include fibroblasts, macrophages, ECM, EC, lymphatic EC, and other inflammatory cells (Fig. [29] This may also play a role in TH9 tumor suppression (see "Physiological functions" above). Dynamic adhesion characterization of cancer cells under blood flow-mimetic conditions: effects of cell shape and orientation on drag force. Burelli: «Operiamo fino a sera per ridurre le attese. [15] Once activated, phosphorylated STAT6 mediate the transcription of Gata3 and Irf4, which are both necessary for polarization of TH9 cells. The following complex cascade of events occurs during metastasis: Tumor cells invade the surrounding stroma and ECM and intravasate into the bloodstream, survive in the blood circulation with anoikis resistance, and then become disseminated through the circulation to reach distant organs, where they proceed to extravasate and invade into the parenchyma of distant tissues. This is the reason why only few tumor cells reach the metastatic organs, although millions of these cells are shed from a tumor into circulation every day.55 However, the viable circulating EC have been reported to be observed in the blood of cancer patients.56, 57 These results led to the conclusion that activated EC expressing high levels of adhesion molecules can bind to tumor cells, protect them from anoikis in circulation, and facilitate their movement to distant organs.54, Our group has reported the role of TEC in the initial steps of tumor metastasis.39 We have previously demonstrated the heterogeneity of TEC using two different types of TEC: HM‐TEC from highly metastatic and LM‐TEC from low metastatic tumors.58 HM‐TEC exhibited more proangiogenic phenotypes with the upregulation of angiogenesis‐related genes and more genetic instability with stem‐like phenotype and drug resistance, indicating that TEC acquire specific characteristics in response to their surrounding environment. [29] They have been shown to inhibit melanoma cell growth,[30][31] increase anti-tumor lymphocytes, and drastically lower tumor mass and disease severity. [37], A higher percentage of TH9 cells in patients with chronic HCV was linked to higher levels of liver enzymes, more severe disease progression and faster development of HCC. %PDF-1.3 3b). Label-Free Imaging of Blood Vessels in Human Normal Breast and Breast Tumor Tissue Using Multiphoton Microscopy. Prefetto furibondo: «Ora l'indagine, ma avvertite prima», Le storie dei veneti guariti dal Coronavirus: andate e ritorno dall'inferno. CAF, cancer‐associated fibroblast; TAM, tumor‐associated macrophage. A 3-cm cutoff point separates T1 from T2 tumors, whereas a size larger than 3 cm is not ascribed any prognostic value. [18], STAT5, downstream factor of IL-2, induce TH9 cells IL-9. TH9 cells appear to be linked to many pathophysiological processes. Silvia Motta. Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review. Reprinted from Maishi, By continuing to browse this site, you agree to its use of cookies as described in our, orcid.org/http://orcid.org/0000-0002-7968-6062, I have read and accept the Wiley Online Library Terms and Conditions of Use, The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited, Accessories to the crime: functions of cells recruited to the tumor microenvironment, Tumor‐associated endothelial cells with cytogenetic abnormalities, Heterogeneity of tumor endothelial cells and drug delivery, Microenvironmental regulation of tumor progression and metastasis, The biology and function of fibroblasts in cancer, Tumors: wounds that do not heal. Cysteine Cathepsins: Potential Applications in Diagnostics and Therapy of Malignant Tumors. CXCR7 on tumor vasculature is also involved in tumor progression and metastasis. Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma. [22] Few studies have reported distinct correlations of in vivo IL-9 with serum IgE concentration. Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics. Our study, as well as other recent studies, has proved the critical role of angiocrine signals in stimulating tumor progression and metastasis. In addition, biglycan levels in the plasma of cancer patients were higher than those in healthy volunteers. Understanding the molecular mechanisms underlying tumor metastasis is crucial to control this fatal disease. In addition to these functions, EC play an important role in the direct molecular regulation of tumor cell behavior. described that TEC convert indolent tumor cells to more aggressive cells with greater tumorigenicity, extranodal invasion, and chemoresistance.42, 43 Moreover, other groups have also demonstrated that the Notch signals in EC are involved in tumor progression and stem cell phenotype.44-47 Notch activation in EC promotes tumor cell migration and metastasis along with neutrophil infiltration.48. Cytokines play a major role in development of TH9 cells. Pore‐Scale Modeling of Fluid‐Fluid Interfacial Area in Variably Saturated Porous Media Containing Microscale Surface Roughness. Review, T2 tumors larger than five centimeters in diameter can be upgraded to T3 in non-small cell lung cancer, The International Association for the Study of Lung Cancer (IASLC) worldwide educational program on lung cancer - A keynote address presented by the President of the IASLC. TH9 have been shown to play a role in both early and progressive phase of multiple sclerosis by decreasing the effects of pro-inflammatory TH17. Nanoparticle Interactions with the Tumor Microenvironment. Furthermore, we highlight the role of TEC in promoting tumor metastasis. and you may need to create a new Wiley Online Library account. Because tumor cells physically contact with TEC during tumor intravasation, we speculated that TEC, especially HM‐TEC with abnormal phenotypes, affect tumor cell behavior. TNM System is impaired when survival rates come from different inhomogeneous countries,... A literature review of the initial attempt to correlate tumor size in NSCLC with the expectancy of survival is presented starting from the 60s. Tumor blood vessels supply nutrients and oxygen and also provide the route for metastasis. MiR‐873 inhibition enhances gefitinib resistance in non‐small cell lung cancer cells by targeting glioma‐associated oncogene homolog 1. Tumor metastasis is the main cause of cancer‐related death. In addition to the production of factors that simulate tumor cell progression, TEC also downregulate tumor suppressive factors. Artificial Cells, Nanomedicine, and Biotechnology. Additionally, they are defined by their high secretion of interleukin‑9. Several molecular pathways orchestrate the complex biological cell events during a metastatic cascade. Learn about our remote access options, Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan. Numbers of molecules enhance or dampen IL-9 production and contribute to TH9 development such as: Activin A that can fully substitute the role of TGF-β in TH9 cells,[21] then Jagged2, programmed cell death ligand (PD-L2), cyclooxy- genase (COX)-2, 1,25-dihydroxyvitamin D3, calcitonin gene-related peptide (CGRP), tumor necrosis factor receptor superfamily member 4 (TNFRSF4 or OX40), and thymic stromal lymphopoietin (TSLP). TAM are proposed to share M2 characteristics and enhance tumor angiogenesis, resulting in tumor progression.18 TAM facilitate tumor cell intravasation through a paracrine signaling loop in which TAM‐derived EGF stimulates the invasiveness of tumor cells expressing the EGF receptor. The formation of new blood vessels, termed as tumor angiogenesis, is a requirement for tumor progression. TEC‐biglycan stimulates Toll‐like receptor (TLR)‐expressing tumor cells to metastasize by activation of nuclear factor‐kappa B (NF‐κB) and extracellular signal‐regulated kinase (ERK) signaling. Fifty-two selected patients were classified according to the primary site and stage of disease and critically evaluated according to the results of surgical treatment. /Width 138 [7][8], IL-1 may induce IL-9 in some cases, and IL-33 is able to induce IL-9 in T cells generally. Via Ernesto Lugaro n. 15 - 00126 Torino - P.I. The authors have reconsidered the clinical problem of centrally located lung tumors from the advanced point of view of tracheobronchoplastic surgical approach. Journal of Thoracic and Cardiovascular Surgery (1). Tumor stromal cells are also known to secrete several protumorigenic factors to promote tumor growth and development.3 We studied TEC and observed several specific characteristics.4, 5 Because blood vessels surrounding tumors not only deliver nutrients and oxygen but also provide access for the tumor cells to metastasize, we assumed that TEC with abnormal phenotypes actively interact with tumor cells during tumor metastasis. Growth factors, such as TGF‐β, PDGF, and FGF, released by tumor cells are key mediators of CAF activation. [9] Generally IL-1 family members enhance expression of Il9 gene. The prognosis of 545 patients with non-s... BACKGROUND: In this keynote address presented at the American Cancer Society International Conference on Prevention and Early Diagnosis of Lung Cancer, Varese, Italy, in 1998, the genesis and the activities of the International Association for the Study of Lung Cancer (IASLC) are outlined. Interaction between malignant tumor cells and their associated stromal cells in the tumor microenvironment is crucial for tumor progression. . Endogenous DAMPs, Category II: Constitutively Expressed, Injury-Modified Molecules (Cat. This may also play a role in T H 9 tumor suppression (see "Physiological functions" above). Among the TNM criteria, tumor size is a well-assessed factor in the prognosis of small tumors. . /BitsPerComponent 8 Statistical Modelling and Machine Learning Principles for Bioinformatics Techniques, Tools, and Applications. Biglycan knockdown in HM‐TEC decreased the number of circulating tumor cells and lung metastases in vivo. Yadav et al.54 demonstrated the role of EC in protecting tumor cells from anoikis in the circulation. SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9. MiR-629-5p promotes the invasion of lung adenocarcinoma via increasing both tumor cell invasion and endothelial cell permeability. Domenico Albano, Francesco Bertagna, Mattia Bertolia, Giovanni Bosio, Silvia Lucchini, Federica Motta, Maria Beatrice Panarotto, Alessia Peli, Luca Camoni, Frank M. Bengel, and Raffaele Giubbini . 3a). It is now well known that bidirectional interaction between tumor cells and their microenvironment, including tumor stroma, is important for tumor progression and metastasis. 1 0 obj 2). Tumor metastasis is the main cause of cancer‐related death. Because of high IFP and immature structure of tumor blood vessels lacking smooth muscles and pericytes, tumor cells easily permeate through tumor blood vessels.40 In addition to this passive entry route, TEC with abnormal phenotype, as described above, may also provide signals that actively promote tumor cells to metastasize. Amidation, Esterification, and Thioesterification of a Carboxyl‐Functionalized Covalent Organic Framework. Controlled Synthesis of a Vacancy‐Defect Single‐Atom Catalyst for Boosting CO2 Electroreduction. In 1971, Judah Folkman proposed that all tumors are angiogenesis dependent.24 Angiogenesis, defined as the growth of new blood vessels from the existing vasculature, is activated in response to the requirement for oxygen and nutrients.25 VEGF (known as vascular permeability factor) is one of the major molecules released from tumor cells to induce angiogenesis. UMBERTO MOTTA ... cato un tumore. Recent studies have emphasized “angiocrine factors” that are released from tumor endothelial cells and promote tumor progression. Th9 cells can differentiate either from naive T lymphocytes or by a shift from TH2 cells. /Type/XObject A VEGFR2–MICA bispecific antibody activates tumor-infiltrating lymphocytes and exhibits potent anti-tumor efficacy in mice. Perineurioma of the colon: an uncommon tumor with an unusual location. All rights reserved. [14], IRF4 binds to the promoter of Il-9 gene in TH9 cells and it is dependent on STAT6. Does endobronchial lesion affect the lymph node status in non-small cell lung cancer? Computational and Structural Biotechnology Journal. [1] Besides IL-9, TH9 cells also produce IL-10 and IL-21. Cancer therapy, which includes surgical resection, chemotherapy, and radiotherapy to control primary tumors, has resulted in improved survival of cancer patients. Staging Syst... Spiral or helical technology is a new computed tomographic technique based on the continuous acquisition of volumetric CT data during continuous x-ray beam rotation and continuous patient transportation at constant velocity. However, their functions in TH9 cells are still unclear.[2]. These non‐malignant stromal cells exhibit abnormal phenotypes compared with those in normal tissues. Collectively, we and other groups identified an alternative role for TEC in facilitating tumor metastasis with orchestrating tumor cells and their microenvironment. Most silvia motta tumore related news are at: arrgianf.blogspot.com – Blogger Musica: Buongiorno Buonasera è il nuovo singolo di Vittorio Merlo 11 May 2013 | 02:19 pm. A compared Italian cumulative experience, TNM staging system of lung carcinoma: historical notes, limitations and controversies, [Spiral computed tomography in the diagnosis and staging of bronchopulmonary carcinoma], [Lobar bronchoplasty for tumor. Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis. The role of protein disulphide isomerase AGR2 in the tumour niche. We also thank Enago for the English language review. Learn more. E adesso che si puntava al recupero dei tempi di attesa sia per gli screening che per gli interventi chirugici, di nuovo la mannaia delle restrizioni sta calando sui reparti. TAM are also known to be important components of tumor stroma. «Virus arrivato dal Ca’ Foncello», Party danzanti del Garden a pranzo. Between 1978 and 1994, 55 patients (53 men and 2 women) with a mean age of 62 years underwent an extended lobectomy to the main bronchus, with bronchial re-anastomosis, for bronchogenic tumours located around the lobar orifice. I diritti delle immagini e dei testi sono riservati. /Length 107450 Nanotechnology is an important strategy for combinational innovative chemo-immunotherapies against colorectal cancer. GGP modified daunorubicin plus dioscin liposomes inhibit breast cancer by suppressing epithelial–mesenchymal transition. Mountain first adapted this classification to lung cancer in 1973 on behalf of AJCC. Several studies have revealed that TAM promote tumor progression and metastasis,15 although macrophages play an important role in the immune defense mechanism. Tumor endothelial cells, which line tumor blood vessels, also exhibit several altered phenotypes compared with those of their normal counterparts. Recently, the clinical onset of combined therapy protocols, the recognised value of the intrathoracic sta... Will Rogers phenomenon affects survival statistics applied to clinical research and could determine a misreading of results. The double-edged sword role of fibroblasts in the interaction with cancer cells; an agent-based modeling approach. Biglycan from tumor endothelial cells stimulates the tumor cells to metastasize. Therapeutic Advances in Medical Oncology. [12] All mentioned cytokines then signal through specific transcription factors, which are later on required for a TH9 polarization. -Glycosylation regulates ligand-dependent activation and signaling of vascular endothelial growth factor receptor 2 (VEGFR2) It was also observed that the epigenetic modification that occurred in the tumor microenvironment was also involved in the increased expression of biglycan in TEC.39. In the literature the postoperative mortality rate varies between 1.8 and 11.4% [2. Superati i 3 mila morti per il Covid in Veneto, nell'ultimo giorno altri 52 decessi, Focolaio all’Oras di Motta, 22 casi. Number of times cited according to CrossRef: Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming. We thank the members of the Vascular Biology Institute of Genetic Medicine, Hokkaido University for the helpful discussions. Working off-campus? ... 5,6 Although feasible in selected patients, there is insufficient evidence to support routine resection of solitary adrenal metastasis. Until 2000, very few articles regarding sublobar resections have been published in western countries, and these works were mostly little case series (4)(5). Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues. (a) Biglycan expression in mouse normal skin tissues and indicated tumors dissected from mouse. Sources of TAM are tissue‐resident macrophage, bone marrow, or spleen. The patient was given adjuvant chemotherapy. Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression. The larger size was connected with an increased risk of metastatic diffusion. What do we have to do... more? Similarities between tumor stroma generation and wound healing, Carcinoma‐associated fibroblasts direct tumor progression of initiated human prostatic epithelium, Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF‐1/CXCL12 secretion, Tumor cell interactions with the extracellular matrix during invasion and metastasis, The stromal proteinase MMP3/stromelysin‐1 promotes mammary carcinogenesis, PAR1 is a matrix metalloprotease‐1 receptor that promotes invasion and tumorigenesis of breast cancer cells, Cancer‐associated fibroblasts are activated in incipient neoplasia to orchestrate tumor‐promoting inflammation in an NF‐kappaB‐dependent manner, Macrophage diversity enhances tumor progression and metastasis, Exploring the full spectrum of macrophage activation, Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm, Macrophages: obligate partners for tumor cell migration, invasion, and metastasis, A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors, Macrophages promote the invasion of breast carcinoma cells via a colony‐stimulating factor‐1/epidermal growth factor paracrine loop, Direct visualization of macrophage‐assisted tumor cell intravasation in mammary tumors, CXCL12‐CXCR7 axis is important for tumor endothelial cell angiogenic property, Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche, Tumor angiogenesis: therapeutic implications, Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis, Probing the structural and molecular diversity of tumor vasculature, Imaging of angiogenesis: from microscope to clinic, Cellular abnormalities of blood vessels as targets in cancer, Lymphoma‐specific genetic aberrations in microvascular endothelial cells in B‐cell lymphomas, Cytogenetic abnormalities of 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metastasis via epigenetic dysregulation of biglycan, Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood, Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors, Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance, Molecular checkpoint decisions made by subverted vascular niche transform indolent tumor cells into chemoresistant cancer stem cells, Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self‐renewal of cancer stem‐like cells, Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged‐1, Endothelial cells provide a notch‐dependent pro‐tumoral niche for enhancing breast cancer survival, stemness and pro‐metastatic properties, Endothelial Jagged1 promotes solid tumor growth through both pro‐angiogenic and angiocrine functions, Endothelial Notch1 activity facilitates metastasis, Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium, CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor‐associated vasculature, CXCR7: a novel tumor endothelial marker in renal cell carcinoma, Elucidation of CXCR7‐mediated signaling events and inhibition of CXCR4‐mediated tumor cell transendothelial migration by CXCR7 ligands, Endothelial CXCR7 regulates breast cancer metastasis, Tumor‐associated endothelial cells promote tumor metastasis by chaperoning circulating tumor cells and protecting them from anoikis, Quantitation of cell shedding into efferent blood of mammary adenocarcinoma, Resting and activated endothelial cells are increased in the peripheral blood of cancer patients, Increased levels of viable circulating endothelial cells are an indicator of progressive disease in cancer patients, Heterogeneity of tumor endothelial cells: comparison between tumor endothelial cells isolated from high‐ and low‐metastatic tumors.
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